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Carlos Severo Dutra-Filho Selected Research

Maple Syrup Urine Disease

1/2021Preliminary results of PBA-loaded nanoparticles development and the effect on oxidative stress and neuroinflammation in rats submitted to a chemically induced chronic model of MSUD.
11/2016L-carnitine Prevents Oxidative Stress in the Brains of Rats Subjected to a Chemically Induced Chronic Model of MSUD.
10/2015Investigation of inflammatory profile in MSUD patients: benefit of L-carnitine supplementation.
5/2015L-Carnitine supplementation decreases DNA damage in treated MSUD patients.
5/2015Urinary biomarkers of oxidative damage in Maple syrup urine disease: the L-carnitine role.
9/2014Prevention of DNA damage by L-carnitine induced by metabolites accumulated in maple syrup urine disease in human peripheral leukocytes in vitro.
2/2013Protein and lipid damage in maple syrup urine disease patients: l-carnitine effect.
3/2007Synaptic plasma membrane Na(+), K (+)-ATPase activity is significantly reduced by the alpha-keto acids accumulating in maple syrup urine disease in rat cerebral cortex.
9/2006A chemically-induced acute model of maple syrup urine disease in rats for neurochemical studies.
6/2005alpha-keto acids accumulating in maple syrup urine disease stimulate lipid peroxidation and reduce antioxidant defences in cerebral cortex from young rats.
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Carlos Severo Dutra-Filho Research Topics

Disease

15Maple Syrup Urine Disease
01/2021 - 03/2003
11Phenylketonurias (Phenylketonuria)
01/2016 - 05/2002
10Body Weight (Weight, Body)
06/2018 - 05/2002
6Cystinosis
05/2008 - 06/2004
5Inborn Genetic Diseases (Disease, Hereditary)
01/2021 - 08/2006
5Tyrosinemias (Tyrosinemia)
01/2015 - 10/2008
4Metabolic Diseases (Metabolic Disease)
10/2015 - 08/2003
4Neurodegenerative Diseases (Neurodegenerative Disease)
06/2008 - 07/2006
4Familial Hypertryptophanemia
06/2008 - 06/2003
2Hyperglycemia
01/2018 - 05/2015
2Sarcosinemia
01/2017 - 04/2016
2Histidinemia
12/2012 - 05/2012
2Brain Injuries (Brain Injury)
06/2008 - 07/2006
2Brain Diseases (Brain Disorder)
02/2007 - 12/2004
2Glutaric Acidemia I
02/2007 - 02/2003
22-Hydroxyglutaricaciduria
10/2003 - 05/2003
1Neuroinflammatory Diseases
01/2021
1Dyskinesias (Dyskinesia)
02/2018
1Rare Diseases (Rare Disease)
01/2018
1B-Cell Lymphoma (Lymphoma, B Cell)
01/2018
1Obesity
12/2015
1Inborn Errors Metabolism (Inborn Errors of Metabolism)
05/2015
1hypoglycemic encephalopathy
12/2014
1Zellweger Syndrome (Zellweger's Syndrome)
03/2014
1Hyperlysinemias (Hyperlysinemia)
03/2014
1Peroxisomal Disorders (Peroxisomal Disorder)
03/2014
1Infantile Refsum Disease (Infantile Phytanic Acid Storage Disease)
03/2014
1Hemolytic Anemia
06/2010
1Glutathione synthetase deficiency
06/2010
1Acidosis
06/2010

Drug/Important Bio-Agent (IBA)

12Phenylalanine (L-Phenylalanine)FDA Link
01/2016 - 05/2002
9Branched-Chain Amino AcidsIBA
01/2021 - 03/2003
9AcidsIBA
11/2016 - 05/2003
8Amino AcidsFDA Link
01/2017 - 05/2003
8Keto AcidsIBA
10/2015 - 03/2003
7Oxidoreductases (Dehydrogenase)IBA
11/2016 - 10/2003
7EnzymesIBA
05/2015 - 06/2004
7Tyrosine (L-Tyrosine)FDA Link
01/2015 - 10/2008
7Tryptophan (L-Tryptophan)FDA Link
06/2008 - 06/2003
7Cystine (L-Cystine)IBA
05/2008 - 06/2004
5Leucine (L-Leucine)FDA Link
01/2021 - 03/2003
5Carnitine (L-Carnitine)FDA LinkGeneric
10/2015 - 02/2013
5AntioxidantsIBA
10/2015 - 06/2005
5Cysteamine (Mercaptamine)FDA Link
05/2008 - 06/2004
4Isoleucine (L-Isoleucine)FDA Link
01/2021 - 02/2013
4Valine (L-Valine)FDA Link
01/2021 - 02/2013
4Pharmaceutical PreparationsIBA
02/2018 - 06/2004
4Glucose (Dextrose)FDA LinkGeneric
12/2015 - 03/2003
4Phenylalanine Hydroxylase (Phenylalanine 4 Monooxygenase)IBA
09/2014 - 05/2002
3Alanine (L-Alanine)FDA Link
06/2018 - 03/2003
3CreatineIBA
01/2017 - 09/2011
3Creatine Kinase (Creatine Phosphokinase)IBA
09/2011 - 04/2005
3KynurenineIBA
02/2007 - 06/2003
3Sulfhydryl Compounds (Thiols)IBA
08/2006 - 06/2004
3Pyruvate KinaseIBA
10/2005 - 03/2003
2Saline SolutionIBA
06/2018 - 04/2016
2Streptozocin (Streptozotocin)FDA Link
01/2018 - 05/2015
2Insulin (Novolin)FDA Link
01/2018 - 12/2014
2Proteins (Proteins, Gene)FDA Link
01/2018 - 02/2013
2Sarcosine (Methylglycine)IBA
01/2017 - 04/2016
2LipidsIBA
12/2015 - 02/2013
2Histidine (L-Histidine)FDA Link
12/2012 - 05/2012
2Tyrosine Transaminase (Tyrosine Aminotransferase)IBA
05/2012 - 09/2009
2Lactic Acid (Lactate)FDA LinkGeneric
05/2008 - 03/2003
2Adenosine Triphosphatases (ATPase)IBA
03/2007 - 02/2007
23-hydroxykynurenineIBA
02/2007 - 12/2006
2Proline (L-Proline)FDA Link
11/2003 - 06/2003
1Triglycerides (Triacylglycerol)IBA
02/2018
1Haloperidol (Haldol)FDA LinkGeneric
02/2018
1Fish OilsIBA
02/2018
1Free RadicalsIBA
02/2018
1NanocapsulesIBA
02/2018
1OilsIBA
02/2018
1p38 Mitogen-Activated Protein KinasesIBA
01/2018
1JNK Mitogen-Activated Protein KinasesIBA
01/2018
1Glycogen Synthase (Synthase I)IBA
01/2018
1bcl-2-Associated X Protein (bcl 2 Associated X Protein)IBA
01/2018
1Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA
01/2018
1Glycine (Aminoacetic Acid)FDA LinkGeneric
01/2017
1Pyruvic Acid (Pyruvate)IBA
01/2017
1NADPH Oxidases (NAD(P)H oxidase)IBA
05/2015
1Biomarkers (Surrogate Marker)IBA
05/2015
1Clonazepam (Rivotril)FDA LinkGeneric
12/2014
1pipecolic acidIBA
03/2014
1CatalaseIBA
03/2013
1Superoxide DismutaseIBA
03/2013
1Thioctic Acid (Lipoic Acid)IBA
03/2013
1Histidine Ammonia-LyaseIBA
12/2012
1phenylpyruvic acidIBA
10/2012
1phenylacetic acid (phenylacetate)FDA Link
10/2012
13-phenyllactic acidIBA
10/2012
1Biological ProductsIBA
05/2012
1tyrosine methyl esterIBA
05/2012
1Pyrrolidonecarboxylic Acid (Pyroglutamic Acid)IBA
06/2010
1HHH syndromeIBA
11/2009
1OrnithineIBA
11/2009
1homocitrullineIBA
11/2009

Therapy/Procedure

2Therapeutics
01/2021 - 05/2015
2Subcutaneous Injections
06/2008 - 03/2008
1Injections
06/2018